The rapper is currently performing in his Before I Self Destruct tour, and took to the stage at London`s Wembley Arena on Saturday. He decided to take a swipe at Heather, the ex-wife of Beatles legend Sir Paul McCartney, by altering the lyrics to one of his best known tracks Do You Think About Me?
Heather lost part of her leg when she was hit by a police motorbike in 1993, and now works with amputees. She and Paul divorced in 2008 and she received a settlement of £24.3 million, which many felt was too high as the marriage lasted less than four years.
50 poked fun at the controversial relationship in his rap, causing the crowd to whoop with delight. "It`s like Paul McCartney stuck in my head, fell in love with a b***h walked away with one leg," he rapped. "She ain`t even have to run to get away with the bread."
It wasn`t the only part of the show which got the crowd cheering. Later, the rapper chose a woman at random and shouted: "Do I know you? Haven`t we f**ked before?"
He then placed his microphone over his private parts and launched into a rendition of his track She`s My London Girl.