The former `Friends` actress - who was married to Hollywood heartthrob Brad Pitt for five years before divorcing in 2005 - topped the poll conducted by Vanity Fair magazine and TV show `60 Minutes` claiming 29 per cent of the vote.
The 41-year-old actress - currently single despite recently being linked to former boyfriend John Mayer and Hard Rock heir Harry Morton - narrowly beat `Monster`s Ball` star Halle Berry to the title in the telephone poll of 906 Americans.
Halle - who recently split from model Gabriel Aubry, the father of her two-year-old daughter Nahla - received 21 per cent of the vote.
Tiger Wood`s ex-wife Elin Nordegren, who recently received a rumoured $60 million divorce settlement from the cheating golfer, came third with 15 per cent, while 88-year-old comedienne Betty White - who has been single since her husband Allen Ludden passed away in 1981 - came fourth with 11 per cent.
Eccentric singer Lady Gaga received five per cent of the vote, even though she is reportedly planning to marry her boyfriend Luc Carl in a British Castle in December.
Associate Justice of the Supreme Court of the United States Elena Kagan came last with four per cent.