The Jamaican singer - best known for his 1982 track `Night Nurse` - has passed away this morning (25.10.10) aged 59 after a battle with cancer.
According to reports by the BBC Caribbean, Isaacs - nicknamed the Cool Ruler and Lonely Lover - died at his London home.
Friends said he had originally been diagnosed with cancer of the liver which had then spread. He is survived by wife. Linda, and children.
Gregory had a prolific career, releasing over 50 albums over four decades. His last album, `Brand New Me` was released in 2008 to very positive reviews.
Only days ago Gregory`s Linda admitted her husband was "not well" but declined to make further comment.
Singer George Nooks said he had recently spoken with Gregory, and told the Jamaica Observer newspaper: "I don`t know just what will happen, but I do know that God can turn things around. My prayers are with Gregory."