The `Proposal` actor - who is married to actress Scarlett Johansson, who was named Babe of the Year by GQ magazine this week - was awarded the title by the publication in their annual list and, although he expects to be teased by his family about the accolade, he is hoping to boast about the title to strangers.
He said: "You just have to go with the flow. This gives my family entre into teasing me for the rest of my life.
"Now it`s going to be, `Sexiest man, take out the garbage.` That does sound better. The most difficult part is going to be organically working this title into a conversation with random strangers."
While Ryan has been namedSexiest Man Alive, he admits he has to work hard to maintain his toned physique.
He joked to People: "My body naturally wants to look like Dick Van Dyke. When I stop training, I turn into a skin-coloured whisper."
Other stars to feature in the list include `Mad Men` actor John Hamm, `Twilight Saga` hunk Kellan Lutz, actor-turned-rapper Drake and `Glee` star Matthew Morrison, who made up the top five.
Making up the rest of the top 10 were Jon Bon Jovi, `True Blood` star Joe Manganiello, Robert Downey Jr. and `Grey`s Anatomy` star Jesse Williams.
Meanwhile, the publication also ran a poll on social networking website Facebook, where fans voted Vin Diesel - who placed eleventh in the magazine`s own list - as their Sexiest Man Alive.
The 43-year-old actor took the title over Jersey Shore`s Paul `Pauly D` DelVecchio and Enrique Iglesias, who polled second and third place respectively.
People will publish its full list of the Sexiest Men Alive in their next issue which hits newsstands on Friday (19.11.10).