The reality TV star - who recently signed a deal to star in her own fly-on-the-wall show with husband Lamar Odom - is said to be expecting the couple`s first child and it is thought the new programme will follow her pregnancy.
A source told the New York Post newspaper that the 26-year-old socialite "has been hiding a tell-tale bump behind flowing dresses and oversized handbags."
Khloe - who tied the knot with Los Angeles Lakers star Lamar in September 2009 after a whirlwind one-month romance - is said to have become broody after her older sister Kourtney gave birth to her son Mason, who is now 12 months old.
A family friend said: "Khloe was inspired by Kourtney having a baby. Lamar is happy and ecstatic."
While Khloe`s representatives have refused to confirm or deny the rumours she is keeping her fans guessing with an enigmatic post on her twitter page hinting at exciting developments in her life.
She wrote: "No one can define who I am but ME! I set my own rules! I create my destiny!"
Khloe recently revealed her excitement at the `Newlyweds`-style format of her new show with Lamar which will follow the couple as they go about their day-to-day lives.
She said: "Ok dolls, it`s official! Lamar and I will soon begin filming our very own show on E! called `Khloe & Lamar`! WOOOOHOOOOOOOO! How exciting is this?! It`s been an option since we got married, but we wanted to enjoy our first year in private.
"With Keeping Up with the Kardashians, only a very small part of our life together is shown, but with this show, we`re putting it ALL out there LOL. Trust me, there will be a lot of laughs. Lamar and I could not be more thrilled about this. It`s show time baby!!!! (sic)"