The `OMG` hitmaker and his protege have been confirmed to appear at the awards - which take place on February 13 in Los Angeles - to give a special performance alongside `Karate Kid` actor Jayden Smith, son of rapper-turned-actor Will Smith.
Another trio made up of B.o.B, Bruno Mars and Janelle Monae will also perform together at the annual awards show, and nominees Muse and Lady Antebellum have also been confirmed to take to the stage.
Stars already listed to perform include Eminem, Lady Gaga, Katy Perry, Arcade Fire, Cee Lo Green and Miranda Lambert.
The line up now means all five Album of the Year nominees - Eminem, Arcade Fire, Lady Gaga and Katy Perry are scheduled to perform at the show.
Eminem leads the night`s awards with 10 nominations, and his producer, Alex Da Kid - who worked on his recent hit `Love The Way You Lie` - warned that after two albums in as many years, he is liable to release new material at any time.
Alex told MTV: "We`re constantly working and we never know what projects the things we`re working on will land. I think he`s in a great position where him and Dr. Dre can make music and whenever they feel like it, they can put it out.
"There`s not a label telling them what to do, because they`ve been so successful, it`s really up to him."