The American dance group - fronted by James Murphy - say they will play their last ever gig at New York`s Madison Square Garden on April 2.
In a statement released on their website, the band said: "We are retiring from the game. gettin` out. movin` on. but for just one more night, we will be playing with friends and family for nearly 3 hours -playing stuff we`ve never played before and going out with a bang. and we`d like you to be there. (sic)"
The `North American Scum` hitmakers have also requested fans attend the concert, which they have described as a "funeral", dressed in black and white.
They said: "if you would, we`d love it if people came in all white. or black. or black and white. and come early, as the festivities will be opened by our favourites, liquid liquid. yes: liquid liquid.
"if it`s a funeral, lets have the best funeral ever!!! (sic)"
LCD Soundsystem have been threatening to quit the music business for some time, hinting last year their current album `This Is Happening` would be their last.
While promoting the record, James said: "It`s over. That`s one of the primary reasons I`m out of here. It`s not necessarily a bad thing for me because I`m 40 years old and I make albums.
"I`m an oldish dude with a much older music sensibility. I was already anachronistic when I was 30, now I`m just laughable."