The White Stripes singer and his model wife made the announcement via a party invitation where they asked guests to help them celebrate their "sixth anniversary and their upcoming divorce".
The couple - who have two children Scarlett, five and Henry Lee, three - added in a statement: "We remain dear and trusted friends and co-parents to our wonderful children Scarlett and Henry Lee. We feel so fortunate for the time we have shared and the time we will continue to spend both separately and together watching our children grow. In honour of that time shared, we are throwing a divorce party. An evening together in Nashville to re-affirm our friendship and celebrate the past and future with close friends and family."
Jack and Karen`s anniversary/divorce party took place in Nashville on 10.06.11 and they have promised "dancing, photos, memories and drinks with alcohol in them".
The invitation added: "This is only for close personal friends so please no plus ones or dead beats. Please help us celebrate together this anniversary of the making and breaking of the sacred union of marriage with our best friends and animals."
Jack was previously married to his White Stripes drummer Meg White and the singer - who real last name is Gillis - took Meg`s last name and kept it after their 2000 divorce.