The `Celebration` singer - who adopted five-year-old son David from the African country in 2006, followed by six-year-old daughter Mercy in 2009 - wants to redouble her efforts to aid orphaned children by opening a new centre as well as giving financial support to current ones.
Speaking in new TV documentary `American Revolutionaries: The Hitmakers`, she said: "My short term goals are to build an orphan care centre that will service and reach at least 1,000 children and I`m also actively involved in funding several orphanages that already exist."
However, Madonna`s aspirations for the country were dealt a blow earlier this year after her plans to build a school for girls were "discontinued".
The 52-year-old star had pledged to build an academy following her adoption of David in 2006, but the $3.8 million she had put into the project through her charitable foundation Raising Malawi failed to develop into an educational establishment.
Madonna - who also has biological children Lourdes, 14, and 10-year-old Rocco - admitted she was "frustrated" at the development because of the lack of education in the country.
She said in a statement: "There is a real education crisis in Malawi, 67 per cent of girls don`t go to secondary school.
"Our team is going to work hard to address this in every way we can."