John Cleese was upset for "two years" following the breakdown
The three-times wed actor is grateful he stayed friends with Connie Booth - who he married in 1968 - after they split because they shared so much "love" for one another.
He said: "When Connie and I broke up in 1978, I was very upset for about two years. There was a great deal of love in that relationship, and we`ve managed to remain good friends."
John split with third wife Alyce Faye Eichelberger in 2008 and had to pay her a divorce settlement worth around £12 million.
Because of the cost of the split, John returned to the stage and while he is enjoying his `Alimony` tour, he admits he prefers writing material.
He told the new issue of Reader`s Digest magazine: "It`s the first time I`ve been on my own stage, and I like the immediacy of it. If you don`t get the laugh tonight, you can change the joke and try again the next night
"I prefer writing, but it pays much less, so I have to keep performing."