The 32-year-old actress - who married the concert producer in Rome in 2010 - has reportedly cited irreconcilable differences as the reason behind the split, according to legal papers obtained by gossip website TMZ.com.
Filed on 13.01.12 at the Los Angeles Superior Court by the `American Pie` star`s attorney Mark Gross, the divorce documents state November 1 as the date of separation and Mena is said to be keen for a judge to prevent Simone from gaining spousal support from her.
In November, Mena insisted the couple planned to have children together in the future, but were putting it off for the moment because of her husband`s work commitments.
She exclusively told BANG Showbiz: "We are kind of building our lives together, we`ve been married a year now. He`s more in the music industry and he travels a lot as well but we`ve been able to travel together.
"Will we have kids? Yeah, one day, one day, hopefully."
This will be Mena`s second divorce after ending her five-year marriage to cinematographer Robert Brinkmann in 2005.