The British comedian - who announced his divorce from Katy Perry last December - will present the June 4 ceremony at the Gibson Amphitheatre in Universal City, California, for the first time, and he insists the event will be "more impressive" than recent box office sensation `Avengers Assemble`.
He said: "This MTV MovieAwardswill be more impressive than `The Avengers` and you won`t have to wait an hour for someone to Hulk out."
Stephen Friedman, president of MTV, is delighted Russell - who hosted the MTV Video Music Awards in 2008 - has signed up to front the film awards, and he believes the `Despicable Me` actor`s "rock `n` roll sensibility and fearlessness" make him the "perfect" choice for the role.
He explained: "With his amazing ability to span the full spectrum of comedy from the most high to lowbrow, Russell`s smart, unpredictable wit uniquely connects him to our audience.
"His rock `n` roll sensibility and fearlessness give us the perfect partner with whom to take a leap of faith with as we meld the worlds of movies and music together on one very special night."
Mila Kunis, Kristen Stewart, Emma Stone, Andrew Garfield, Charlize Theron, Michael Fassbender, Mark Wahlberg and Chris Hemsworth were all recently announced as presenters for the event, which sees `The Hunger Games` and `Bridesmaids` up for eight nominations apiece, including Movie of the Year.
The 2012 MTV MovieAwardswill be screened on Monday June 4 on MTV at 9pm, and voting for the accolades is available at MovieAwards.MTV.com until June 2.