The `Family Guy` creator has been chosen to present the 85th Academy Awards and bring his fresh brand of comedy to the prestigious ceremony on February 24 next year.
Seth released a statement saying: "It`s truly an overwhelming privilege to be asked to host the Oscars. My thoughts upon hearing the news were, one, I will do my utmost to live up to the high standards set forth by my predecessors; and two, I hope they don`t find out I hosted the Charlie Sheen roast."
Producers Craig Zadan and Neil Meron commented: "We are thrilled to have SethMacFarlanehost the Oscars. His performing skills blend perfectly with our ideas for making the show entertaining and fresh.
"He will be the consummate host, and we are so happy to be working with him."
The `Ted` director has been nominated for 13 Emmys and two Grammys over the course of his career and is best known for comedy cartoon series `Family Guy`, `Cleaveland` and `American Dad`.
He was also chosen to kick off comedy programme `Saturday Night Live``s 38th season, receiving rave reviews by critics.
The funnyman recently suffered a mishap while presenting an award to the Reality Show Host Emmy Award winner when he spoke into a switched-off microphone.
Seth joked: "This is what happens when you don`t come to rehearsal. That`s gonna be on YouTube."
The comedian follows in the footsteps of illustrious Academy Award hosts including Billy Crystal, Steve Martin and Whoopi Goldberg.