The 10-year-old son of David and Victoria Beckham - stars in the spring/summer 2013 campaign for the British brand alongside Cara Delevigne and Edie Campbell and has been praised as a "joy to work with".
Chief creative officer Christopher Bailey said: "This season`s campaign lights up with the infectious energy of an amazing young cast of old and new Burberry family. We had such fun shooting the campaign and I think that comes through in the images, which really reflect the upbeat spirit of the collection."
The campaign was shot by Mario Testino and features a mixture of Burberry Prorsum, Burberry London and Burberry Brit clothing.
Romeo recently attended the red carpet premiere of the Spice Girls musical `Viva Forever` along with his brothers Brooklyn, 13 and seven-year-old Cruz and father David, all clad in Burberry.
Fashion designer Victoria - who also has daughter Harper, 17 months, with David - recently spoke about Romeo`s love of fashion.
She said: "I think that my middle son thinks that he is going to take over. Romeo likes to get involved, he likes to go out in a suit with a bowler hat. He`s a real fashion lover."