The duo starred in 2004 movie `Taking Lives` together and although he has kissed numerous other women onscreen, Ethan, 42, - who has two children with wife Ryan - insists none of them can compare to Angelina.
Speaking to Andy Cohen on `Watch What Happens Live`, he said: "With all due respect - the woman has been in the press a lot lately - but my best onscreen kiss was with AngelinaJolie.
"AngelinaJolie was born to whittle men, to make them weak. And when she kisses you, you don-t know your name."
Angelina`s fiance Brad Pitt evidently feels the same way as it was recently revealed he kisses her whenever possible.
The couple`s eight-year-old little girl Zahara suggested the `World War Z` actor, 49, can`t keep his hands off his 37-year-old partner - with whom he also has five other children, Maddox, 11, Pax, nine, Shiloh, six, and four-year-old twins Knox and Vivienne - when they`re at home.
Brad`s close friend and furniture business partner Frank Pollaro said: "Once I walked in and Angie was standing there and Zahara walked up and said, `Daddy, you`re not going to start making out with Mommy again, are you?` And it`s like that.
"This is a guy who has tried not to do any sexy scenes with other women since he`s met Angelina. He`s crazy about her, and she`s the same way about him."