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DAME (Dam), Henrik

( Danish biochemist, Nobel Prize in Physiology or Medicine, 1943)

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Biography DAME (Dam), Henrik
February 21, 1895, Mr.. - April 17, 1976
Carl Peter Henrik Dam, Danish biochemist, was born in Copenhagen in the family of Emil Dame pharmacists, author of historical and biographical books, and Emily (Peterson) Dam, teacher. He studied chemistry at the Copenhagen Polytechnic Institute and received a master's degree in 1920,. Three years D. teaches chemistry at the Royal Agricultural School, and in 1923. - The physiological laboratory of biochemistry at the University of Copenhagen.
1925. D. at the University of Graz, Austria, studying the micro-chemical analysis (qualitative and quantitative analysis of small quantities of substances) with Fritz Pregl. Returning to Copenhagen, he became in 1928. assistant professor at the Institute of Biochemistry at the University, and the next year, Associate Professor. For his thesis on the biological study of sterols he receives his Ph.D. in 1934
Between 1928 and 1930., Studying the metabolism of cholesterol in chicks, D. made his first discoveries concerning vitamin K. This phenomenon can be explained by any known factors of diet. Funded by the Rockefeller Foundation, Dr.. continued his studies with Rudolf Sheyngeymerom in Freiburg, Germany, in 1932 ... 1933. and in Zurich (Switzerland), two years later. There, in collaboration with Paul Karrer D. D

. Analyzing chemical structure vitamin K, Eduard And. Doisy at University Saint-Luis showed that his animals and vegetable forms slightly differ. Third synthetic form, vikasol, used in clinic for prophylaxis bleedings.
D. learned that intestinal bacteria produce vitamin K y animals and Rights and, since y majority healthy people synthesized sufficient quantities vitamin, bleedings arising his absence in diet, rare. Until opening vitamin K bleeding during surgical interventions and bleedings caused such, eg, diseases as jaundice, often proved deadly. Patients suffering zhelchnokamennoy disease or violations outflow bile caused other causes, experienced huge risk during operation due possible deadly bleedings. High risk of bleeding was also in patients with certain bowel diseases, such as for example, and celiac sprue, for those receiving treatment with antibiotics or anticoagulants, in newborn infants with low prothrombin. It was found that the introduction of vitamin K in such cases prevents fatal bleeding. Moreover, the usual dose of vitamin K, assigned to pregnant women before delivery and newborn children significantly reduced mortality among infants.
Funded by the American-Scandinavian Foundation, Dr.. in 1940. went to lecture in Canada and the U.S.. After the Nazi occupation of Denmark, he decided to stay in the United States, conducting research, first in the laboratory of Marine Biology and Forest in 1941, then in the next three years at the University of Rochester as a senior researcher.
In 1945, Mr.. He became a member of the Rockefeller Institute for Medical Research (now Rockefeller University).
For the discovery of vitamin K D. was awarded the Nobel Prize in Physiology or Medicine in 1940, which he shared with E. Doisy. Because of the Second World War, regular awards ceremony was interrupted. D. and Doisy received an award from the Swedish Ambassador to the United States at a special ceremony in New York under the auspices of the Swedish-American Foundation. D. read Nobel lecture 'discovery of vitamin K, its biological functions and therapeutic application' ( 'The Discovery of Vitamin K, Its Biological Functions and Therapeutical Application') in 1946
. During his stay abroad Copenhagen Polytechnic Institute chose D
. in 1941. Professor of Biochemistry. By taking this position in 1946, he continued the study of vitamins K and E, fat, cholesterol, and conditions for the formation of stones in the gallbladder, the results of these studies he has published over 100 articles. From 1956 to 1962. D. worked as the head of the biochemical department of the Danish Council for the Exploration of fat.
In 1924, Mr.. D. married Inger Olsen, the Danish, they have no children. He died in Copenhagen on 17 April 1976
D. was a member of the American Society for Biochemistry, . American Institute of Nutrition, . Botanical Society of America, . Royal Academy of Sciences of Denmark, . Danish Biological Society, . Swiss Chemical Society and American Society of Experimental Biology and Medicine.,


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