The `Two and a Half Men` actor was taken out of his Los Angeles home on a stretcher and loaded into an ambulance at 7am, before being taken to the nearby Cedars-Sinai Hospital.
According to gossip website TMZ, Charlie - who was accompanied by two women - was having severe abdominal pains after throwing a wild party, which triggered a phone call to the emergency services.
He is now believed to resting at the hospital and his actor father Martin Sheen and his mother Janet Templeton are with him.
The news comes just days after Charlie hooked up with three porn stars in Las Vegas.
The 45-year-old star and the women - who were in the US gambling city for a porn convention - went on an "epic bender" at The Palms Hotel and Casino, before heading back to his hotel room.
The drinking session followed Charlie firing his sober coach, who had been hired after he trashed a New York hotel room and was found naked by police.
A source said: "The sober coach never went back to work for Charlie. He has not heard from Charlie since he told him not to start New Year`s Day (01.01.11)."
The hotel room incident capped off a bad year for the Charlie.
Following a fight with his estranged wife Brooke Mueller - mother of his 22-month-old twin sons, Bob and Max - on Christmas Day 2009, he paid a trip to rehab and received a 30-day suspended prison sentence for misdemeanour assault.
During his New York trip to October, Charlie was accused of causing $7,000 worth of damage to his hotel suite after tossing furniture around because of the monetary demands of the escort.
Before the alleged incident, the actor - who was enjoying a mini-break with his ex-wife Denise Richards and their daughters Sam, six, and five-year-old Lola - was reportedly found by his assistant naked and covered in cocaine in a restaurant toilet.