The 35-year-old rapper - whose real name is Curtis Jackson - grew up not knowing his father and was raised by his grandmother from the age of 12 after his mother was murdered aged just 27.
Speaking on forthcoming VH-1 documentary `50 Cent: The Origin Of Me`, 50 told a group of students in South Carolina: "It feels good for me to learn more about my actual history. A lot of people don`t know but I`m adopted.
"Yeah, my grandmother adopted me after my mother passed away. So she`s like my legal guardian. My grandparents were from out here so the last time I was out here I was like six years old."
The documentary uncovered evidence that some of 50`s distant relatives had been slaves for prominent citizens, but the rapper doesn`t believe their oppression had any impact in his early misdemeanours, including dealing drugs in New York.
Writing for Vanity Fair magazine, documentary maker David Kamp revealed the rapper told him: "I don`t necessarily see a connection between stuff that happened 200 years ago in Edgefield and stuff that happened to me on the south side of Jamaica, Queens. Some people just choose to be bad."