The couple - whose 14-year relationship has been rumoured to be in trouble for several months - have confirmed they have "amicably" parted ways and appealed for privacy for the sake of their two children, Lily-Rose, 13, and 10-year-old Jack.
A statement from their representatives read: "JohnnyDepp and VanessaParadishave amicably separated. Please respect their privacy and, more importantly, the privacy of their children."
News of the split comes just a month after it was claimed the couple - who have not appeared in public together for over a year - were "working on" getting their relationship back on track.
A source said recently: ``For the first time in a long time, he is talking about her. They both want to make it work.``
And the `Dark Shadows` star recently blasted untrue speculation about his relationship being over.
He said: ``The rumours are not true. They are absolutely not true.`
``No matter what I say about this, people believe the opposite. I can`t say enough about it not being over.``