The 51-year-old actor - who was diagnosed with Parkinson`s disease in 1991 - will come out of his early retirement to star in an upcoming Sony Pictures Television comedy in 2013 which is inspired by his own life.
He is teaming up with `Easy A` director Will Gluck and writer Sam Laybourne, who has worked on `Cougar Town` and `Arrested Development`, Vulture reports.
Michael rose to fame in 1980s sitcom `Family Ties` before making his big screen debut in `Back to the Future` as time-travelling teen Marty McFly.
The actor then starred in the hugely popular political sitcom `Spin City`, but quit his television career in 2000 to focus on his health and set up the Michael J. Fox Foundation to help find a cure for the degenerative condition.
He has made several minor guest appearances on TV shows since, however, including `Rescue Me`, `Curb Your Enthusiasm` and `The Good Wife`. Michael also had a recurring role on comedy `Boston Legal`.
The star told ABC News in May that his new drug regimen is allowing him to take on more roles because his tics are under control.