The 53-year-old actor - who has 16-year-old daughter Ireland with ex-wife Kim Basinger - admits he has considered the "fantastic" possibility of starting a family with his 27-year-old girlfriend, yoga instructor named Hilaria Thomas.
He said: "Have I thought about having more kids? Oh sure, that would be great, that would be heaven, that would be fantastic."
He jokingly added: "As my friend said to me, `When you have children, typically in a second marriage, when you`re older and you get married again to a woman who would have children, you must always remember that you make sure the children attend a college where the commencement ceremonies are held in a facility with a wheelchair accessible ramp,` "
The `30 Rock` star was resigned to leading an "unhappy" life alone before he met Hilaria, who he has been dating since last March.
He told TV talk show host Piers Morgan: "It is true what people always say, and it`s tough to make your way to that place, I guess, where you stop looking.
"I was married and I was with somebody for 10 years and then after I got divorced, I dated people and I had one girlfriend for several years... and right before I met Hilaria.
"I did lay in my bed and say, `This is it. I`m gonna be alone for the rest of my life, I`m gonna die alone in this apartment in this bed, I`ll have my friends, I`ll have twitter, I`ll have Words with Friends, I`ll have my New Yorker subscription... I`ll have my quiet, unhappy life`, and then right when I put it all on the shelf, and it was over I walked into a restaurant and I met this woman who is probably one of the greatest people I`ve ever met in my life."